A Cry Act



Yingjie Wang


Gao Group


Friday, November 10, 2017 - 4:00pm


Cryptochromes, Cry, are photoreceptors that absorb blue light and mediate signaling events to modulate a wide range of biological functions such as circadian entrainment and phototropism. The signaling activation is triggered by excitation of the flavin adenine dinucleotide cofactor, followed by protein conformational changes that mediate protein-protein interaction with downstream partners. In this presentation, I will discuss the conditions and functional dynamics of drosophila cryptochrome through a plethora of molecular dynamics simulation and analysis tools. Our model recapitulates various experimental evidence of dCry activation, and the mechanism may be applicable to other cryptochromes.